Many customers… find it challenging to use existing standards for materials that are traditionally used for the same application. They need to have specific data that they can compare against for their submission to the FDA.
— Debby Cohen, Director, Admet Inc., USA
  • BEST provides solutions to problems caused by improper and fragmented pre-clinical testing.

  • BEST uses integrated approach, based on a fundamental principle: there is no specimen response before the stimulus applied.

  • BEST experimental data are post-processed without use of an explicit material model, based on idempotent analysis (patents pending). There BEST integrates specimen history and extracts unknown values.

  • BEST is performed under controlled conditions with required coherent stimuli. It assesses changes in properties of the specimen in time, phase and stimulus domains.

  • BEST invariant parameters show the position and the direction of development of your biomaterial and provide solid data for its optimization.

 
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  • BEST aims to non-destructively characterize specimens at coherent conditions, closer to physiological reality.

    • Does not require assumptions on material linearity, specimen homogeneity, geometric and intermode linearities

    • Testing comprises high-output coherent screening, incorporating specimen history dependence

    • Non-destructive evaluation in most cases - you may reprocess the specimen

    • No need for using complex numbers algebra or transforms

    • Previous data maybe reprocessed without need for new experiments

  • Depending on the purpose, BEST can evaluate many readouts (in many cases, from a single specimen or test), such as:

    • Aggregate modulus

    • Characteristic times of the material reactivity

    • Channel size (effective size) for porous and permeable specimens

    • Compliance to different applied stresses

    • Dynamic true modulus

    • Fluid diffusivity / mobility (for fluid-filled specimens) in statics and dynamics

    • Fluid source/rate (for fluid filled specimens) in statics and dynamics

    • Injection kinetics and injectability (e.g. from a prefilled syringes into tissue phantoms)

    • Material permeability / permittivity

    • Material memory function (in statics and dynamics)

    • Material properties map (invariant values)

    • Potential changes in the specimen fine structure and properties

    • Shear modulus (in a special sample holder setup)

    • Slope modulus (within compliance analysis)

    • Swelling pressure / kinetics

    • True stress and strain

    • Viscosity (real time and invariants)

BEST measures properties for the purpose - the same material may have different properties vs. conditions like media, temperature, etc., so it is important the values are exactly what you need for that medical application your biomaterial has its intended purpose.